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题名: The neurotoxicity of DE-71: effects on neural development and impairment of serotonergic signaling in zebrafish larvae
作者: Wang, Xianfeng1, 2; Yang, Lihua1; Wang, Qiangwei3; Guo, Yongyong1; Li, Na4; Ma, Mei4; Zhou, Bingsheng1
关键词: PBDEs ; zebrafish larvae ; neural development ; serotonergic system ; molecular docking
刊名: JOURNAL OF APPLIED TOXICOLOGY
发表日期: 2016-12-01
DOI: 10.1002/jat.3322
卷: 36, 期:12, 页:1605-1613
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
英文摘要: The underlying mechanism of polybrominated diphenyl ether (PBDE)-induced neurotoxicity is still a major concern due to its ubiquitous nature and persistence. Here, zebrafish embryos (2h postfertilization, hpf) were exposed to different concentrations of the commercial PBDE mixture DE-71 (0-100 mu gl(-1)) until 120 hpf, and the impact on neural development and serotonergic system was investigated. The in vivo results revealed significantly reduced transcription of genes involved in neurogenesis (fgf8, shha, wnt1), and contents of proteins in neuronal morphogenesis (myelin basic protein, synapsin IIa), suggesting an impairment of neural development in zebrafish embryos. Further results demonstrated a reduction of 5-hydroxytryptamine neuron and a dose-dependent decrease of whole-body serotonin levels, as well as the transcription of genes involved in serotonergic synthesis (tph1, tph2, trhr) and neurotransmission (serta/b, htr1aa/b). In addition, we predicted possible targets of PBDEs by molecular docking, and the results indicated that PBDE congeners showed high binding affinities with fibroblast growth factor 8 other than SHH and HTR1B. Taken together, this study demonstrated that PBDE exposure during embryogenesis could damage neural development and cause impairment of the serotonergic system as secondary effects in the zebrafish larvae. Copyright (c) 2016 John Wiley & Sons, Ltd.
关键词[WOS]: POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; WNT/BETA-CATENIN PATHWAY ; NEURONAL DIFFERENTIATION ; IN-SILICO ; BRAIN ; EXPOSURE ; DISRUPTION ; EXPRESSION ; DISORDERS
语种: 英语
项目资助者: National Natural Science Foundation of China(21307153 ; National Environmental Protection Public Welfare Science and Technology Research Program of China(201309047) ; Knowledge Innovation Program of the Chinese Academy of Sciences(Y25E03) ; 21237005)
WOS记录号: WOS:000385782200009
ISSN号: 0260-437X
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/28667
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou 310058, Zhejiang, Peoples R China
4.Chinese Acad Sci, State Key Lab Environm Aquat Chem, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China
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